About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3586594
Allelic
Composition
Igh-Jtm1Mcdl/Igh-Jtm1Mcdl
Igk-Jtm1Mcdl/Igk-Jtm1Mcdl
Rag1tm1Mom/Rag1tm1Mom
Tg(DO11.10)10Dlo/?
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Mcdl mutation (0 available); any Igh-J mutation (11 available)
Igk-Jtm1Mcdl mutation (0 available); any Igk-J mutation (8 available)
Rag1tm1Mom mutation (31 available); any Rag1 mutation (62 available)
Tg(DO11.10)10Dlo mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold

hematopoietic system
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Job's syndrome DOID:3261 OMIM:147060
J:100072


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory