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Phenotypes Associated with This Genotype
Genotype
MGI:3586594
Allelic
Composition
Igh-Jtm1Mcdl/Igh-Jtm1Mcdl
Igk-Jtm1Mcdl/Igk-Jtm1Mcdl
Rag1tm1Mom/Rag1tm1Mom
Tg(DO11.10)10Dlo/?
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Mcdl mutation (0 available); any Igh-J mutation (11 available)
Igk-Jtm1Mcdl mutation (0 available); any Igk-J mutation (8 available)
Rag1tm1Mom mutation (27 available); any Rag1 mutation (45 available)
Tg(DO11.10)10Dlo mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold (J:100072)

hematopoietic system
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold (J:100072)
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold (J:100072)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant 147060 J:100072


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory