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Phenotypes Associated with This Genotype
Genotype
MGI:3584512
Allelic
Composition
Tg(Amelx)42Msnd/Tg(Amelx)42Msnd
Genetic
Background
involves: C57BL/6J * CBA/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Amelx)42Msnd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• transmission electron microscopy of the enamel matrix of neonatal incisors reveals non-uniformity in the size of the self-assembled amelogenin nanospheres and disruption of the normally evenly-spaced, parallel arrangement of the hydroxyapatite crystallites
• scanning electron micrographs of incisors of 6 week old mice reveal loss of the normal boundary definiton of the rods comprising the enamel and abnormal porosity of the structure formed by the rods

craniofacial
• transmission electron microscopy of the enamel matrix of neonatal incisors reveals non-uniformity in the size of the self-assembled amelogenin nanospheres and disruption of the normally evenly-spaced, parallel arrangement of the hydroxyapatite crystallites
• scanning electron micrographs of incisors of 6 week old mice reveal loss of the normal boundary definiton of the rods comprising the enamel and abnormal porosity of the structure formed by the rods

growth/size/body
• transmission electron microscopy of the enamel matrix of neonatal incisors reveals non-uniformity in the size of the self-assembled amelogenin nanospheres and disruption of the normally evenly-spaced, parallel arrangement of the hydroxyapatite crystallites
• scanning electron micrographs of incisors of 6 week old mice reveal loss of the normal boundary definiton of the rods comprising the enamel and abnormal porosity of the structure formed by the rods

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Amelogenesis Imperfecta, Type IE; AI1E 301200 J:100004


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory