About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3584471
Allelic
Composition
Trp53tm1Tyj/Trp53tm3.1Tyj
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (146 available)
Trp53tm3.1Tyj mutation (2 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53tm1Tyj homozygotes (55% compared to 66%)

mortality/aging
• mean life span is 4.6 months
• a slight decrease is seen in the number of females born

neoplasm
• 43% have multiple tumors
• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53tm1Tyj homozygotes (55% compared to 66%)
• carcinomas are seen in 18% of mice, with most carcinomas showing signs of invasion, metastasis, or other features of advanced human carcinomas
• most carcinomas are derived from epithelial cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory