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Phenotypes Associated with This Genotype
Genotype
MGI:3584470
Allelic
Composition
Trp53tm3.1Tyj/Trp53+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm3.1Tyj mutation (2 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life span is 15.8 months (J:95316)
• mean life span is 15.8 months (J:95316)

tumorigenesis
• compared to Trp53tm1Tyj (J:95316)
• compared to Trp53tm1Tyj (J:95316)
• 5 of 36 develop B cell lymphomas generally arising in the spleen or mesenteric lymph nodes (J:95316)
• 5 of 36 develop B cell lymphomas generally arising in the spleen or mesenteric lymph nodes (J:95316)
• the incidence of carcinomas is increased compared to Trp53tm1Tyj heterozygotes (J:95316)
• 5 of 36 develop squamous cell carcinomas and a single case each of transitional cell renal carcinoma and intestinal carcinoma are seen (J:95316)
• the incidence of carcinomas is increased compared to Trp53tm1Tyj heterozygotes (J:95316)
• 5 of 36 develop squamous cell carcinomas and a single case each of transitional cell renal carcinoma and intestinal carcinoma are seen (J:95316)
• 7 of 36 develop lung adenocarcinomas, several with malignant features commonly seen in human lung adenocarcinoma including nuclear atypia (5 of 7), desmoplasia (4 of 7), and metaplasias (2 of 7) (J:95316)
• 7 of 36 develop lung adenocarcinomas, several with malignant features commonly seen in human lung adenocarcinoma including nuclear atypia (5 of 7), desmoplasia (4 of 7), and metaplasias (2 of 7) (J:95316)
• 2 of 36 develop hepatocellular carcinomas (J:95316)
• 2 of 36 develop hepatocellular carcinomas (J:95316)
• 5 of 36 develop squamous cell carcinomas (J:95316)
• 5 of 36 develop squamous cell carcinomas (J:95316)

cellular
• resistance to gamma-irradiation induced apoptosis is increased compared to Trp53tm1Tyj hterozygotes (J:95316)
• resistance to gamma-irradiation induced apoptosis is increased compared to Trp53tm1Tyj hterozygotes (J:95316)
• a larger fraction of MEFs are in S phase compared to Trp53tm1Tyj hterozygotes; however DNA damage-induced G1 arrest is intact (J:95316)
• a larger fraction of MEFs are in S phase compared to Trp53tm1Tyj hterozygotes; however DNA damage-induced G1 arrest is intact (J:95316)

Mouse Models of Human Disease
OMIM ID Ref(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95316


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory