Phenotypes Associated with This Genotype

Genotype
MGI:3584256

• Allelic Composition: Bdnf^tm1Krj/Bdnf^tm1Lfr; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84683 )

nervous system

abnormal medium spiny neuron morphology ( J:96903 )

• the cross-sectional area of medium spiny neuron soma is reduced by 25% and the diameter of all portions of the dendritic tree is reduced by about 40% compared to wild-type mice with spine density reduced by 30-40% at every order of dendrite

decreased striatum size ( J:96903 )

• the striatal volume is reduced by 15% at P14 and by 33% and P35 and P120

abnormal hippocampus morphology ( J:96903 )

• hippocampal volume is reduced by 12% at 14 days of age however by 120 days of age no significant reduction in hippocampal volume is seen

abnormal cerebral cortex morphology ( J:96903 )

• cortical volume is reduced by 16% at P14, by about 25% at P35, and by 30% at P120

abnormal visual cortex morphology ( J:84683 )

• in layer II/III of the visual cortex soma area is normal at 2 weeks of age but reduced by 28% and 29% at 3 and 5 weeks of age, respectively; however the number of neurons is not significantly different compared to wild-type mice

• in layer II/III of the visual cortex basal dendrite branching is normal at 2 weeks of age, but reduced by 29% at 5 weeks of age with distal branches more severely affected than proximal branches

• in layer II/III of the visual cortex the number of primary dendrites is normal at 2 weeks of age but reduced by 19% and 36% at 3 and 5 weeks of age, respectively, compared to wild-type mice

thin cerebral cortex ( J:84683 )

• at 5 weeks of age the thickness of the somatosensory and visual cortex are reduced by 12% and 17%, respectively and a 22% increase in neuron density is seen in layer II/III of the visual cortex compared to wild-type mice

behavior/neurological

increased aggression ( J:84683 )

limb grasping ( J:96903 )

• all mutants display limb clasping by 120 days of age and clasping progresses with age from only hindlimbs to include hind and forlimbs; however no impairment od motor function is seen in the rotarod test

abnormal nest building behavior ( J:84683 )

growth/size/body

decreased body weight ( J:84683 )

• body weight is reduced at 3 and 5 weeks of age

obese ( J:84683 )

• a 35% increase in body mass is seen at 16 weeks of age

reproductive system

reduced fertility ( J:84683 )

vision/eye

delayed eyelid opening ( J:84683 )

• mutants open their eyes 1 day later