Mouse Genome Informatics
hm
    Ins2Akita/Ins2Akita
C57BL/6-Ins2Akita
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

homeostasis/metabolism
• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice
• blood glucose levels are slightly higher at 1 day of age and much higher at 14 days of age with no gender differences seen

endocrine/exocrine glands
• alpha cell density is markedly increased
• density of beta cells is decreased within 24 hours of birth and at 2 weeks of age
• beta cell granules are fewer in number and smaller and mitochondrial swelling and an increase in endoplasmic reticulum are seen at 2 weeks of age
• islet area is reduced
• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Permanent Neonatal; PNDM 606176 J:47883