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Phenotypes Associated with This Genotype
Genotype
MGI:3583906
Allelic
Composition
Ins2Akita/Ins2Akita
Genetic
Background
C57BL/6-Ins2Akita
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2Akita mutation (13 available); any Ins2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

homeostasis/metabolism
• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice (J:47883)
• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice (J:47883)
• blood glucose levels are slightly higher at 1 day of age and much higher at 14 days of age with no gender differences seen (J:47883)
• blood glucose levels are slightly higher at 1 day of age and much higher at 14 days of age with no gender differences seen (J:47883)

endocrine/exocrine glands
• alpha cell density is markedly increased (J:47883)
• alpha cell density is markedly increased (J:47883)
• density of beta cells is decreased within 24 hours of birth and at 2 weeks of age (J:47883)
• beta cell granules are fewer in number and smaller and mitochondrial swelling and an increase in endoplasmic reticulum are seen at 2 weeks of age (J:47883)
• density of beta cells is decreased within 24 hours of birth and at 2 weeks of age (J:47883)
• beta cell granules are fewer in number and smaller and mitochondrial swelling and an increase in endoplasmic reticulum are seen at 2 weeks of age (J:47883)
• islet area is reduced (J:47883)
• islet area is reduced (J:47883)
• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice (J:47883)
• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice (J:47883)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Permanent Neonatal; PNDM 606176 J:47883


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory