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Phenotypes Associated with This Genotype
Genotype
MGI:3583697
Allelic
Composition
Fgl2tm1Pam/Fgl2tm1Pam
Genetic
Background
B6.129X1-Fgl2tm1Pam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgl2tm1Pam mutation (0 available); any Fgl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• resistant to murine hepatitis virus type 3 (MHV-3) induced death

growth/size/body
• mice are smaller at 7 months of age, but not at 6- to 8-weeks of age
• mice weigh less at 7 months of age, but not at 6- to 8-weeks of age, indicating that mice lose weight with age

renal/urinary system
• presence of hemorrhage within the kidney
• progressive increase in the level of albumin in the urine
• progressive increase in the level of blood in the urine
• by 3 months of age, mice show focal segmental mesangial thickening and a mild increase in cellularity of glomeruli
• by 6 months of age, glomerular changes are severe with widespread generalized increase in cellularity, mesangial thickening, and decrease in vascularity
• at 6 months of age, 25% of mice develop severe glomerulonephritis, with characteristically small and yellow kidneys, and show a heavy interstitial inflammatory cell infiltration comprised predominately of lymphocytes
• kidneys show extensive infiltration of mononuclear cells and interstitial fibrosis, collapse of many renal tubules that are surrounded with fibrin and mesangial expansion in the glomerulus
• by 3 months of age, mice show focal segmental mesangial thickening and by 6 months of age, mesangial thickening is more severe
• IgG, IgM, and IgA are seen in glomerular mesangium and the infiltrating cells and C3 deposits are seen at 1, 3, and 6 months of age
• kidneys show fibrosis at 6 months of age
• kidney size is smaller in 25% of mice by 7 months of age
• kidney weight is smaller in 25% of mice at 7 months of age

immune system
• mice show a 30% increase in the proportion and absolute numbers of dendritic cells (CD11c+MHCII+) in the spleen, while the proportions of macrophages are normal
• an increase in the number of dendritic cells is seen from in vitro bone marrow cultures
• iall plasmacytoid and myeloid dendritic cells subsets in the spleen and bone marrow are increased
• increase in the percentage of Treg cells in all lymphoid tissues; the increase corresponds to a higher absolute number of Treg cells in all lymphoid organs
• mice show an increase in numbers of antibody-producing B cells in response to T-independent antigens, LPS, and NP-Ficoll, but normal response to T-dependent antigen NP-CGG
• however, the amount of antibody produced per cell is similar to wild-type mice
• IgA is seen in glomeruli
• however, levels of IgG and IgM autoantibodies against dsDNA, ssDNA, or chromatin in aged mice is normal
• IgG is seen in glomeruli
• IgM is seen in glomeruli
• effector T cells are polarized toward a Th1 response
• T cells have increased proliferation in response to ConA and in a one-way mixed lymphocyte reaction
• CD4+CD25- T cells cultured in the presence of irradiated splenocytes are less efficient in suppressing CD4+ T cell proliferation compared to wild-type T cell, indicating that Treg suppressive activity is impaired
• older mice show decreased number of Peyers Patch follicles
• 25% fewer Peyers Patches in the small intestine of young mice
• older mice show decreased number of intestinal Peyers Patches and follicles
• increase in reactivity of dendritic cells
• apoptosis of LPS-stimulated dendritic cells in culture is decreased and delayed
• at 6 months of age, 25% of mice develop severe glomerulonephritis, with characteristically small and yellow kidneys, and show a heavy interstitial inflammatory cell infiltration comprised predominately of lymphocytes
• kidneys show extensive infiltration of mononuclear cells and interstitial fibrosis, collapse of many renal tubules that are surrounded with fibrin and mesangial expansion in the glomerulus
• resistant to murine hepatitis virus type 3 (MHV-3) induced liver necrosis
• resistant to murine hepatitis virus type 3 (MHV-3) induced death

cellular
• apoptosis of LPS-stimulated dendritic cells in culture is decreased and delayed
• T cells have increased proliferation in response to ConA and in a one-way mixed lymphocyte reaction

hematopoietic system
• mice show a 30% increase in the proportion and absolute numbers of dendritic cells (CD11c+MHCII+) in the spleen, while the proportions of macrophages are normal
• an increase in the number of dendritic cells is seen from in vitro bone marrow cultures
• iall plasmacytoid and myeloid dendritic cells subsets in the spleen and bone marrow are increased
• increase in the percentage of Treg cells in all lymphoid tissues; the increase corresponds to a higher absolute number of Treg cells in all lymphoid organs
• mice show an increase in numbers of antibody-producing B cells in response to T-independent antigens, LPS, and NP-Ficoll, but normal response to T-dependent antigen NP-CGG
• however, the amount of antibody produced per cell is similar to wild-type mice
• IgA is seen in glomeruli
• however, levels of IgG and IgM autoantibodies against dsDNA, ssDNA, or chromatin in aged mice is normal
• IgG is seen in glomeruli
• IgM is seen in glomeruli
• effector T cells are polarized toward a Th1 response
• T cells have increased proliferation in response to ConA and in a one-way mixed lymphocyte reaction
• CD4+CD25- T cells cultured in the presence of irradiated splenocytes are less efficient in suppressing CD4+ T cell proliferation compared to wild-type T cell, indicating that Treg suppressive activity is impaired

homeostasis/metabolism
• increase in serum creatinine with age
• progressive increase in the level of albumin in the urine
• progressive increase in the level of blood in the urine

cardiovascular system
• presence of hemorrhage within the kidney

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autoimmune glomerulonephritis DOID:0040094 J:130895


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory