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Phenotypes Associated with This Genotype
Genotype
MGI:3583687
Allelic
Composition
Gcktm1Tka/Gck+
Irs1tm1Tka/Irs1tm1Tka
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1Tka mutation (0 available); any Gck mutation (35 available)
Irs1tm1Tka mutation (0 available); any Irs1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• these mice exhibit a body weight that is ~70% of that of wild-type mice throughout life
• these mutants display a similar degree of growth retardation as Irs1tm1Tka homozygous mutant mice

homeostasis/metabolism
• these mutants exhibit higher, although not statistically significant, fasting insulin levels (148% of wild-type levels)
• at 15 weeks of age, these mutants display a similar degree of glucose intolerance to Gcktm1Tka heterozygotes
• however, at 30-40 weeks, these mutants exhibit a "diabetic" glucose tolerance i.e. an exacerbated glucose intolerance relative to Gcktm1Tka heterozygotes of the same genetic background
• these mutants exhibit insulin resistance relative to Gcktm1Tka heterozygotes of the same genetic background

endocrine/exocrine glands
• in these mutants, beta-cell mass per pancreas is 216% of wild-type in terms of area
• in contrast, the non-beta (i.e. alpha and delta) cell mass remains unchanged relative to wild-type
• a portion of pancreatic islets from these mutant mice appear enlarged due to beta-cell hyperplasia

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:38899


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory