Mouse Genome Informatics
cx
    Gcktm1Tka/Gck+
Irs1tm1Tka/Irs1tm1Tka

involves: 129X1/SvJ * C57BL/6 * CBA * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• these mice exhibit a body weight that is ~70% of that of wild-type mice throughout life
• these mutants display a similar degree of growth retardation as Irs1tm1Tka homozygous mutant mice

homeostasis/metabolism
• these mutants exhibit higher, although not statistically significant, fasting insulin levels (148% of wild-type levels)
• at 15 weeks of age, these mutants display a similar degree of glucose intolerance to Gcktm1Tka heterozygotes
• however, at 30-40 weeks, these mutants exhibit a "diabetic" glucose tolerance i.e. an exacerbated glucose intolerance relative to Gcktm1Tka heterozygotes of the same genetic background
• these mutants exhibit insulin resistance relative to Gcktm1Tka heterozygotes of the same genetic background

endocrine/exocrine glands
• in these mutants, beta-cell mass per pancreas is 216% of wild-type in terms of area
• in contrast, the non-beta (i.e. alpha and delta) cell mass remains unchanged relative to wild-type
• a portion of pancreatic islets from these mutant mice appear enlarged due to beta-cell hyperplasia

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:38899