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Phenotypes Associated with This Genotype
Genotype
MGI:3583335
Allelic
Composition
Rettm2.1Cos/Ret+
Genetic
Background
involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm2.1Cos mutation (1 available); any Ret mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 16-17% display nodular chromaffin cell hyperplasia, rarely progressing to pheochromocytoma
• 31% of young and 41% of older mutants display diffuse C-cell hyperplasia and 14% have more advanced nodular C-cell hyperplasia

nervous system
• 16-17% display nodular chromaffin cell hyperplasia, rarely progressing to pheochromocytoma


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory