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Phenotypes Associated with This Genotype
Genotype
MGI:3583331
Allelic
Composition
Rettm2.1Cos/Rettm2.1Cos
Genetic
Background
involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm2.1Cos mutation (1 available); any Ret mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• newborns have bilateral malformations of the adrenal glands
• mice show incomplete enclosure of the adrenal medulla
• mice show display nodular chromaffin cell hyperplasia as early as 4 months of age
• at 6-10 months of age, 26% display diffuse C-cell hyperplasia and 60% display more advanced nodular C-cell hyperplasia
• apparent as early as 5 months of age and in every mutant by 6 months of age

nervous system
• mice show display nodular chromaffin cell hyperplasia as early as 4 months of age
• develop ganglioneuromas of the adrenal medulla however do not develop ganglioneuromas of the intestinal tract or mucosa
• consistently display neuromatous enlargement of the sympathetic ganglia along the medial aspect of the adrenal glands and invasion of the sympathetic ganglia into the adrenal gland

neoplasm
• apparent as early as 5 months of age and in every mutant by 6 months of age
• develop ganglioneuromas of the adrenal medulla however do not develop ganglioneuromas of the intestinal tract or mucosa

reproductive system
• 83% of males could not impregnate wild-type females although they exhibited normal mounting behavior and had normal gonads and produced mature sperm


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory