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Phenotypes Associated with This Genotype
Genotype
MGI:3583142
Allelic
Composition
Itgb2tm1Bay/Itgb2tm1Bay
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * PL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm1Bay mutation (1 available); any Itgb2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: 23.5% of the F2 progeny from a PL/J x C57BL/6J intercross develop psoriasiform dermatitis, which is not observed on a 129S7/SvEvBrd or a mixed 129S7/SvEvBrd and C57BL/6J background

integument
N
• Background Sensitivity: F1 mice from intercrosses of homozygotes on PL/J and C57BL/6J backgrounds did not develop progressive dermatitis, however when F1 mice were backcrossed to homozygotes on the PL/J background, 50% developed dermatitis (J:32126)
(J:84126)
• Background Sensitivity: 23.5% of the F2 progeny from a PL/J x C57BL/6J intercross develop psoriasiform dermatitis, which is not observed on a 129S7/SvEvBrd or a mixed 129S7/SvEvBrd and C57BL/6J background
• approximately half of affected F2 mice develop severe disease with various degrees of alopecia
• Background Sensitivity: approximately half of affected F2 mice develop only mild disease with erythema and/or dry skin, which is not observed on a 129S7/SvEvBrd or a mixed 129S7/SvEvBrd and C57BL/6J background
• 23.5% of the F2 progeny from a PL/J x C57BL/6J intercross develop chronic inflammatory skin disease with highly variable severity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
psoriasis DOID:8893 OMIM:PS177900
J:32126 , J:84126


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory