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Phenotypes Associated with This Genotype
Genotype
MGI:3583134
Allelic
Composition
T(2;10)67Gso/T(2;10)67Gso
Genetic
Background
involves: 101 * C3H * C3H/Rl * C57BL/RlGso * SEC/RlGso
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most of those that survive the first day of life die by 3-4 days of age (J:75799)
• most of those that survive the first day of life die by 3-4 days of age (J:75799)
• many homozygotes die immediately after birth (J:75799)
• many homozygotes die immediately after birth (J:75799)

renal/urinary system
• kidneys are bilaterally enlarged and pale (J:75799)
• kidneys are bilaterally enlarged and pale (J:75799)
• elongated cysts that extend radially from the cortex towards the medullary pyramid (J:75799)
• collecting tubules within the cortex are elongated and dilated with cysts which are lined with cuboidal epithelium (J:75799)
• elongated cysts that extend radially from the cortex towards the medullary pyramid (J:75799)
• collecting tubules within the cortex are elongated and dilated with cysts which are lined with cuboidal epithelium (J:75799)

liver/biliary system
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen (J:75799)
• cysts are lined with a single layer of low columnar to cuboidal cells (J:75799)
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen (J:75799)
• cysts are lined with a single layer of low columnar to cuboidal cells (J:75799)
• most homozygotes turn a yellow-orange color before death (J:75799)
• most homozygotes turn a yellow-orange color before death (J:75799)

growth/size/body
• homozytgotes are smaller than unaffected littermates at birth (J:75799)
• homozytgotes are smaller than unaffected littermates at birth (J:75799)
• seen at 1-3 days of age (J:75799)
• seen at 1-3 days of age (J:75799)

behavior/neurological
• homozytgotes are weaker than unaffected littermates at birth (J:75799)
• homozytgotes are weaker than unaffected littermates at birth (J:75799)

endocrine/exocrine glands
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen (J:75799)
• cysts are lined with a single layer of low columnar to cuboidal cells (J:75799)
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen (J:75799)
• cysts are lined with a single layer of low columnar to cuboidal cells (J:75799)

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:75799


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory