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Phenotypes Associated with This Genotype
Genotype
MGI:3583134
Allelic
Composition
T(2;10)67Gso/T(2;10)67Gso
Genetic
Background
involves: 101 * C3H * C3H/Rl * C57BL/RlGso * SEC/RlGso
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most of those that survive the first day of life die by 3-4 days of age
• many homozygotes die immediately after birth

renal/urinary system
• kidneys are bilaterally enlarged and pale
• elongated cysts that extend radially from the cortex towards the medullary pyramid
• collecting tubules within the cortex are elongated and dilated with cysts which are lined with cuboidal epithelium

liver/biliary system
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
• cysts are lined with a single layer of low columnar to cuboidal cells
• most homozygotes turn a yellow-orange color before death

growth/size/body
• homozytgotes are smaller than unaffected littermates at birth
• seen at 1-3 days of age

behavior/neurological
• homozytgotes are weaker than unaffected littermates at birth

endocrine/exocrine glands
• bile ducts are increased in number and dilated and no normal interlobular ducts are seen
• cysts are lined with a single layer of low columnar to cuboidal cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:75799


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory