Phenotypes Associated with This Genotype

Genotype
MGI:3582580

• Allelic Composition: Ocln^tm2Sts/Ocln^tm2Sts
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal salivary gland duct morphology ( J:99467 )

• the striated ducts cells lack characteristic cytoplasmic granules

abnormal gastric chief cell morphology ( J:99467 )

• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with loss of chief cells

abnormal gastric parietal cell morphology ( J:99467 )

• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with severely decreased numbers of parietal cells

abnormal stomach glandular epithelium morphology ( J:99467 )

• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with loss of chief cells, severely decreased numbers of parietal cells and presence of abnormal mucoid-containing cells

• at 40 weeks of age in most of the stomach fundus the epithelium of the gastric glands displays cellular crowding, nuclear pleomorphism, increased nuclear to cytoplasmic ratio, and loss of nuclear polarity

• at 40 weeks of age in some portions of the stomach fundus gastric glands resemble pyloric-like glands with numerous mucoid-containing cells

• however, no malformations or functional defects were detected in the tight junctions of the intestinal epithelium

increased stomach mucosa thickness ( J:99467 )

• by 40 weeks of age the mucosa appears thickened

stomach inflammation ( J:99467 )

• gastritis is seen around 10 weeks of age and becomes severe by 28 weeks of age

immune system

stomach inflammation ( J:99467 )

• gastritis is seen around 10 weeks of age and becomes severe by 28 weeks of age

endocrine/exocrine glands

abnormal salivary gland duct morphology ( J:99467 )

• the striated ducts cells lack characteristic cytoplasmic granules

abnormal gastric chief cell morphology ( J:99467 )

• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with loss of chief cells

abnormal gastric parietal cell morphology ( J:99467 )

• at 3 - 6 weeks of age a marked loss of differentiation of the epithelium in gastric glands is seen with severely decreased numbers of parietal cells

abnormal seminiferous tubule morphology ( J:99467 )

♂ • at 40 - 60 weeks of age atrophy of the seminiferous tubules is seen with atrophied tubules being devoid of germ cells

growth/size/body

postnatal growth retardation ( J:99467 )

• after birth the body weights of homozygotes begins to lag behind wild-type mice and by 8 weeks of age male and female homozygotes are 72% and 77% of normal weight, respectively

behavior/neurological

abnormal nursing ( J:99467 )

♀ • females do not suckle their litters

reproductive system

abnormal seminiferous tubule morphology ( J:99467 )

♂ • at 40 - 60 weeks of age atrophy of the seminiferous tubules is seen with atrophied tubules being devoid of germ cells

male infertility ( J:99467 )

♂ • males but not females are infertile

nervous system

abnormal basal ganglion morphology ( J:99467 )

• progressive accumulation of mineral deposits is seen beginning at 9 weeks of age resulting in concentric, often laminated deposits

abnormal cerebellum morphology ( J:99467 )

• progressive accumulation of mineral deposits is seen beginning at 9 weeks of age resulting in concentric, often laminated deposits

limbs/digits/tail

abnormal femur morphology ( J:99467 )

• compact bone layer is significantly thinner

skeleton

abnormal femur morphology ( J:99467 )

• compact bone layer is significantly thinner

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:99467 )

N • despite calcification in the brain and thinning of compact bone in the femur serum and urine levels of calcium and phosphate are normal