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Phenotypes Associated with This Genotype
Genotype
MGI:3582411
Allelic
Composition
Tlx1tm1Thr/Tlx1tm1Thr
Genetic
Background
involves: 129P2/OlaHsd * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlx1tm1Thr mutation (2 available); any Tlx1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• at E12.5, a significant number of spleen cells undergo apoptosis
• a spleen anlage is present at E11.5 but undergoes rapid and complete resorption between E12.5 and E13.5
• homozygotes are born without a spleen
• however, homozygous mutant mice can survive to birth, develop normally, and are fertile

immune system
• at E12.5, a significant number of spleen cells undergo apoptosis
• a spleen anlage is present at E11.5 but undergoes rapid and complete resorption between E12.5 and E13.5
• homozygotes are born without a spleen
• however, homozygous mutant mice can survive to birth, develop normally, and are fertile

cellular
• at E12.5, a significant number of spleen cells undergo apoptosis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory