Mouse Genome Informatics
tg
    Tg(GFAP)10Mes/0
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• severely affected mice die around 14 days of age; less affected mice live for more than 1 year
• mice display <10% mortality at about 30 days of age

growth/size
• mice show significantly decreased body weights at 6 weeks and three months relative to wild-type

nervous system
• astrocytes are enlarged and contain large eosinophilic aggregations resembling Rosenthal fibers;

Mouse Models of Human Disease
OMIM IDRef(s)
Alexander Disease 203450 J:99256