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Phenotypes Associated with This Genotype
Genotype
MGI:3581611
Allelic
Composition
Tg(Ins2-Fasl)24Ach/0
Genetic
Background
NOD-Tg(Ins2-Fasl)24Ach/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fasl)24Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• majority of mice develop diabetes by 10 weeks of age vs controls which develop diabetes by 12 weeks of age; diabetes determined as blood glucose greater than 250 mg/dl (J:78679)
• mice develop diabetes in ~ 5 days of transfer of diabetogenic T cells (J:81416)

endocrine/exocrine glands
• at 25 weeks of age, transgenic mice show significant islet damage with little remaining insulin

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:78679


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory