Mouse Genome Informatics
tg
    Tg(Ins2-Fasl)24Ach/0
NOD-Tg(Ins2-Fasl)24Ach
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• majority of mice develop diabetes by 10 weeks of age vs controls which develop diabetes by 12 weeks of age; diabetes determined as blood glucose greater than 250 mg/dl (J:78679)
• mice develop diabetes in ~ 5 days of transfer of diabetogenic T cells (J:81416)

endocrine/exocrine glands
• at 25 weeks of age, transgenic mice show significant islet damage with little remaining insulin

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:78679