Phenotypes Associated with This Genotype

Genotype
MGI:3581300

• Allelic Composition: Syngap1^tm1Grnt/Syngap1⁺
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired synaptic plasticity ( J:98903 )

reduced long-term potentiation ( J:98903 )

• reduced long term potentiation in the hippocampal CA1 region (across a wide range of LTP induction protocols) in the absence of any detectable alteration in basal synaptic transmission and NMDAR-mediated synaptic currents

behavior/neurological

abnormal spatial learning ( J:98903 )

• heterozygotes initially learn slower than wildtype in spatial water maze tests, however with further training, exhibit normal learning indicating unimpaired long-term memory