nervous system
• reduced long term potentiation in the hippocampal CA1 region (across a wide range of LTP induction protocols) in the absence of any detectable alteration in basal synaptic transmission and NMDAR-mediated synaptic currents
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behavior/neurological
• heterozygotes initially learn slower than wildtype in spatial water maze tests, however with further training, exhibit normal learning indicating unimpaired long-term memory
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