Phenotypes Associated with This Genotype

Genotype
MGI:3581299

• Allelic Composition: Syngap1^tm1Grnt/Syngap1^tm1Grnt
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:97490 , J:98903 )

• fewer than expected homozygotes were found at P0-P2, however, PO-P2 homozygous pups were normal in size and showed no obvious breathing or feeding difficulties (J:97490)

• pups became ill at around P3-P4 and all died by P7 (J:97490)

• most died within 48 hours after birth, however they were observed to breathe and feed (J:98903)

growth/size/body

decreased body size ( J:97490 )

• P3-P4 pups were smaller than wildtype