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Phenotypes Associated with This Genotype
Genotype
MGI:3581037
Allelic
Composition
Crb1rd8/Crb1rd8
Genetic
Background
STOCK Crb1rd8/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb1rd8 mutation (9 available); any Crb1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice exhibit large, irregularly shaped spots concentrated in the inferior nasal quadrant of the fundus as early as week 3 that correspond to retinal folds and pseudorosettes (J:85459)
• mice exhibit large, irregularly shaped spots concentrated in the inferior nasal quadrant of the fundus as early as week 3 that correspond to retinal folds and pseudorosettes (J:85459)
• retinal thinning in both the inner and outer segment is observed (J:85459)
• retinal thinning in both the inner and outer segment is observed (J:85459)
• Muller cells exhibit increased electron density and cytoplasmic strands that are more easily traced through the plexiform layer than in wild-type mice (J:85459)
• Muller cells exhibit increased electron density and cytoplasmic strands that are more easily traced through the plexiform layer than in wild-type mice (J:85459)
• the photoreceptor lamellae breaks down (J:85459)
• the photoreceptor lamellae breaks down (J:85459)
• in the region of focal degeneration photoreceptors are lost (J:85459)
• in the region of focal degeneration photoreceptors are lost (J:85459)
• the photoreceptor inner segments lose their orderly arrangement (J:85459)
• by 5 months the inner segment approaches the retinal pigment epithelium (J:85459)
• swelling occurs in portions of the inner segments (J:85459)
• the photoreceptor inner segments lose their orderly arrangement (J:85459)
• by 5 months the inner segment approaches the retinal pigment epithelium (J:85459)
• swelling occurs in portions of the inner segments (J:85459)
• at 4 weeks the photoreceptor inner segments are 25% shorter (J:85459)
• at 4 weeks the photoreceptor inner segments are 25% shorter (J:85459)
• by week 10 the outer segment begins to fragment (J:85459)
• by 5 months only a few outer segment fragments remain (J:85459)
• by week 10 the outer segment begins to fragment (J:85459)
• by 5 months only a few outer segment fragments remain (J:85459)
• the photoreceptor outer segments are shortened (J:85459)
• the photoreceptor outer segments are shortened (J:85459)
• the external limiting membrane in the retina is fragmented and disorganized at 2 weeks and is more severe at 4 weeks (J:85459)
• the external limiting membrane in the retina is fragmented and disorganized at 2 weeks and is more severe at 4 weeks (J:85459)
• in older mice, the retinal outer nuclear layer is reduced to a single row of nuclei (J:85459)
• in older mice, the retinal outer nuclear layer is reduced to a single row of nuclei (J:85459)

nervous system
• Muller cells exhibit increased electron density and cytoplasmic strands that are more easily traced through the plexiform layer than in wild-type mice (J:85459)
• Muller cells exhibit increased electron density and cytoplasmic strands that are more easily traced through the plexiform layer than in wild-type mice (J:85459)
• the photoreceptor lamellae breaks down (J:85459)
• the photoreceptor lamellae breaks down (J:85459)
• in the region of focal degeneration photoreceptors are lost (J:85459)
• in the region of focal degeneration photoreceptors are lost (J:85459)
• the photoreceptor inner segments lose their orderly arrangement (J:85459)
• by 5 months the inner segment approaches the retinal pigment epithelium (J:85459)
• swelling occurs in portions of the inner segments (J:85459)
• the photoreceptor inner segments lose their orderly arrangement (J:85459)
• by 5 months the inner segment approaches the retinal pigment epithelium (J:85459)
• swelling occurs in portions of the inner segments (J:85459)
• at 4 weeks the photoreceptor inner segments are 25% shorter (J:85459)
• at 4 weeks the photoreceptor inner segments are 25% shorter (J:85459)
• by week 10 the outer segment begins to fragment (J:85459)
• by 5 months only a few outer segment fragments remain (J:85459)
• by week 10 the outer segment begins to fragment (J:85459)
• by 5 months only a few outer segment fragments remain (J:85459)
• the photoreceptor outer segments are shortened (J:85459)
• the photoreceptor outer segments are shortened (J:85459)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leber Congenital Amaurosis 8; LCA8 613835 J:171736


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory