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Phenotypes Associated with This Genotype
Genotype
MGI:3580533
Allelic
Composition
Prkar1atm1.1Lsk/Prkar1a+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.1Lsk mutation (0 available); any Prkar1a mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• epithelial thyroid cancer

neoplasm
• commonly found on proximal hind limb but elsewhere as well
• interlacing bundles of parallel spindle cells with large eosinophilic cytoplasmic granules
• look like hypertrophic Schwann cells - Schwannomas
• no melanotic pigmentation
• tail tumors as well starting around 5 to 6 months
• bone loss in individual vertebrae of the tail
• epithelial thyroid cancer

Mouse Models of Human Disease
OMIM ID Ref(s)
Carney Complex, Type 1; CNC1 160980 J:98799


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory