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Phenotypes Associated with This Genotype
Genotype
MGI:3580533
Allelic
Composition
Prkar1atm1.1Lsk/Prkar1a+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.1Lsk mutation (0 available); any Prkar1a mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• commonly found on proximal hind limb but elsewhere as well (J:98799)
• interlacing bundles of parallel spindle cells with large eosinophilic cytoplasmic granules (J:98799)
• look like hypertrophic Schwann cells - Schwannomas (J:98799)
• no melanotic pigmentation (J:98799)
• tail tumors as well starting around 5 to 6 months (J:98799)
• bone loss in individual vertebrae of the tail (J:98799)
• commonly found on proximal hind limb but elsewhere as well (J:98799)
• interlacing bundles of parallel spindle cells with large eosinophilic cytoplasmic granules (J:98799)
• look like hypertrophic Schwann cells - Schwannomas (J:98799)
• no melanotic pigmentation (J:98799)
• tail tumors as well starting around 5 to 6 months (J:98799)
• bone loss in individual vertebrae of the tail (J:98799)
• epithelial thyroid cancer (J:98799)
• epithelial thyroid cancer (J:98799)

Mouse Models of Human Disease
OMIM ID Ref(s)
Carney Complex, Type 1; CNC1 160980 J:98799


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory