Mouse Genome Informatics
ht
    Prkar1atm1.1Lsk/Prkar1a+
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• commonly found on proximal hind limb but elsewhere as well
• interlacing bundles of parallel spindle cells with large eosinophilic cytoplasmic granules
• look like hypertrophic Schwann cells - Schwannomas
• no melanotic pigmentation
• tail tumors as well starting around 5 to 6 months
• bone loss in individual vertebrae of the tail
• epithelial thyroid cancer

Mouse Models of Human Disease
OMIM IDRef(s)
Carney Complex, Type 1; CNC1 160980 J:98799