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Phenotypes Associated with This Genotype
Genotype
MGI:3580533
Allelic
Composition
Prkar1atm1.1Lsk/Prkar1a+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.1Lsk mutation (0 available); any Prkar1a mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• epithelial thyroid cancer

neoplasm
• commonly found on proximal hind limb but elsewhere as well
• interlacing bundles of parallel spindle cells with large eosinophilic cytoplasmic granules
• look like hypertrophic Schwann cells - Schwannomas
• no melanotic pigmentation
• tail tumors as well starting around 5 to 6 months
• bone loss in individual vertebrae of the tail
• epithelial thyroid cancer

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Carney complex DOID:0050471 OMIM:160980
OMIM:605244
OMIM:608837
J:98799


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/15/2022
MGI 6.22
The Jackson Laboratory