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Phenotypes Associated with This Genotype
Genotype
MGI:3580520
Allelic
Composition
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
B6.129S2-Tnfrsf1btm1Mwm/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type
• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2
• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

immune system
N
• mice infected with mouse-adapted SARS-CoV MA15 exhibit a modest but non-significant weight loss indicating similar susceptibility to infection as wild-type mice
• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type
• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2
• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2
• CD8+ T cells produce less interferon gamma following anti-CD3 stimulation than control cells; the result of fewer cells expressing interferon gamma as well as a decrease in the amount produced per cell
• CD8+ T cells exhibit a reduction in IL2 secretion following anti-CD3 stimulation

hematopoietic system
• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type
• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2
• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory