Phenotypes Associated with This Genotype

Genotype
MGI:3580520

• Allelic Composition: Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
• Genetic Background: B6.129S2-Tnfrsf1b^tm1Mwm/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

immune system

immune system phenotype ( J:288523 )

N • mice infected with mouse-adapted SARS-CoV MA15 exhibit a modest but non-significant weight loss indicating similar susceptibility to infection as wild-type mice

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

decreased interferon-gamma secretion ( J:107039 )

• CD8+ T cells produce less interferon gamma following anti-CD3 stimulation than control cells; the result of fewer cells expressing interferon gamma as well as a decrease in the amount produced per cell

decreased interleukin-2 secretion ( J:107039 )

• CD8+ T cells exhibit a reduction in IL2 secretion following anti-CD3 stimulation

hematopoietic system

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2