Analysis Tools
renal/urinary system
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• hypoplastic metanephroi with reduced number of glomeruli
• however, morphologically normal medulla and glomeruli
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• neonates had small metanephroi that were functional at birth
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• observed in 40% of mutants
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• greatly reduced numbers of developing nephrons at birth
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• the distal ureter was closed in both sexes
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• the distal ureter ended abnormally in the uterus in some females
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hydroureter
(
J:98831
)
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• observed in 40% of mutants
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• delayed induction of the ureteric bud
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reproductive system
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• 57.1% of mutant females had completely or partially absent uteri with residual uterine tissue discontinuously present
• posterior uterus was more frequently absent compared to the anterior region
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absent uterus
(
J:98831
)
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• 57.1% of mutant females had completely or partially absent uteri
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• absent epididymis in all mutant males
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embryo
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• loss of caudal mesonephric tubules; however, the cranial mesonephros was present
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• exhibited Mullerian duct aplasia, impaired posterior elongation of the Mullerian duct and Mullerian duct degeneration adjacent to where the Wolffian duct was lost
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• degeneration of the nephric (Wolffian) duct epithelium that resulted in the absence of most parts of the reproductive tract in all mutant males, except for some residual tissue
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