Mouse Genome Informatics
tg
    Tg(Crh)227.1Pbl/0
C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• transgenic mice exhibit increased adrenal weights
• transgenic mice show a ~2-fold reduction in thymus weight
• transgenic mice exhibit elevated ACTH release

homeostasis/metabolism
• notably, addition of zinc in the drinking water does not further increase the corticosterone levels in founder mice
• transgenic mice show up to a 10-fold increase in corticosterone levels relative to control non-transgenic littermates; the degree of endocrine dysfunction varies widely among founders
• transgenic mice show a 5-fold elevation in serum levels of ACTH

growth/size
• transgenic mice exhibit truncal obesity with large adipose deposits
• transgenic mice display decreased linear growth relative to non-transgenic littermates

muscle

reproductive system
• transgenic females show decreased fertility probably due to increased corticosterone levels or CRF levels in the brain (J:92996)

hematopoietic system
• transgenic mice show a ~2-fold reduction in thymus weight
• transgenic mice show a 3-fold reduction in spleen weight

immune system
• transgenic mice show a ~2-fold reduction in thymus weight
• transgenic mice show a 3-fold reduction in spleen weight

nervous system
• transgenic mice exhibit elevated ACTH release

integument
• transgenic mice display bilateral symmetric hair loss
• transgenic mice show abnormally transparent skin

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:92996