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Phenotypes Associated with This Genotype
Genotype
MGI:3579981
Allelic
Composition
Fras1bl/Fras1bl
Frem2my-Ucl/Frem2my-Ucl
Genetic
Background
involves: 101/H * C3H/HeH * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fras1bl mutation (2 available); any Fras1 mutation (133 available)
Frem2my-Ucl mutation (0 available); any Frem2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 50% homozygotes died before birth

limbs/digits/tail
• cutaneous syndactyly and occasional bony syndactyly and polydactyly

vision/eye

renal/urinary system
• adult mice (20 weeks) developed renal cysts
• increased proliferation and apoptosis are seen in these cysts

integument
• shows epithelial "blebbing" during embryogenesis starting at E11.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:98344


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory