About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3579773
Allelic
Composition
Nkx3-2tm1(cre)Tsa/Nkx3-2+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-2tm1(cre)Tsa mutation (0 available); any Nkx3-2 mutation (2 available)
Nr2f2tm2.1Tsa mutation (0 available); any Nr2f2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• altered radial patterning and anterior-posterior axis patterning of the stomach (J:98520)
• altered radial patterning and anterior-posterior axis patterning of the stomach (J:98520)
• mesenchyme of the stomach was thickened at E16.5 (J:98520)
• hind-stomach was expanded and exhibited a vacuolated epithelium, resembling the pyloric region, with numerous invaginations and a thickened and disorganized circular smooth muscle layer (J:98520)
• mesenchyme of the stomach was thickened at E16.5 (J:98520)
• hind-stomach was expanded and exhibited a vacuolated epithelium, resembling the pyloric region, with numerous invaginations and a thickened and disorganized circular smooth muscle layer (J:98520)
• reduced size of fore-stomach as indicated by an anterior shift of the limiting ridge (J:98520)
• reduced size of fore-stomach as indicated by an anterior shift of the limiting ridge (J:98520)
• an anterior shift of the limiting ridge is observed (J:98520)
• an anterior shift of the limiting ridge is observed (J:98520)
• the pylorus exhibited a disorganized thickened circular smooth muscle layer, with an epithelium that resembled the epithelium of the duodenum and was devoid of vacuoles, unlike the highly vacuolated control (J:98520)
• the pylorus exhibited a disorganized thickened circular smooth muscle layer, with an epithelium that resembled the epithelium of the duodenum and was devoid of vacuoles, unlike the highly vacuolated control (J:98520)
• number of parietal cells increased in the thickened epithelial layer at E18.5 (J:98520)
• number of parietal cells increased in the thickened epithelial layer at E18.5 (J:98520)
• thicker epithelium at E12.5, E13.5 and E18.5 (J:98520)
• the fore-stomach epithelium did not show signs of stratification at E16.5 and resembled hind-stomach epithelium, indicating posteriorization of stomach (J:98520)
• thicker epithelium at E12.5, E13.5 and E18.5 (J:98520)
• the fore-stomach epithelium did not show signs of stratification at E16.5 and resembled hind-stomach epithelium, indicating posteriorization of stomach (J:98520)
• thicker glandular epithelium at E16.5, however differentiation of this epithelium was unchanged (J:98520)
• exhibited more extensive invagination of the epithelium than in controls (J:98520)
• thicker glandular epithelium at E16.5, however differentiation of this epithelium was unchanged (J:98520)
• exhibited more extensive invagination of the epithelium than in controls (J:98520)
• the circular smooth muscle layer of the stomach was disorganized at E13.5, E14.5 and E15.5 and was thickened in both the fore-stomach and hind-stomach, suggesting that radial patterning of the stomach was perturbed (J:98520)
• the circular smooth muscle layer of the stomach was disorganized at E13.5, E14.5 and E15.5 and was thickened in both the fore-stomach and hind-stomach, suggesting that radial patterning of the stomach was perturbed (J:98520)
• slightly smaller stomach at E12.5 than controls (J:98520)
• slightly smaller stomach at E12.5 than controls (J:98520)

nervous system
• expansion of enteric neurons in the stomach (J:98520)
• expansion of enteric neurons in the stomach (J:98520)

muscle
• the circular smooth muscle layer of the stomach was disorganized at E13.5, E14.5 and E15.5 and was thickened in both the fore-stomach and hind-stomach, suggesting that radial patterning of the stomach was perturbed (J:98520)
• the circular smooth muscle layer of the stomach was disorganized at E13.5, E14.5 and E15.5 and was thickened in both the fore-stomach and hind-stomach, suggesting that radial patterning of the stomach was perturbed (J:98520)

endocrine/exocrine glands
• number of parietal cells increased in the thickened epithelial layer at E18.5 (J:98520)
• number of parietal cells increased in the thickened epithelial layer at E18.5 (J:98520)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diaphragmatic Hernia, Congenital 142340 J:103437


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory