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Phenotypes Associated with This Genotype
Genotype
MGI:3578951
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
BXH2/TyJ-Irf8myls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 10 months of age

immune system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age
• splenocytes did not secrete IFN-gamma in response to LPS treatment
• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma
• increased susceptibility to Mycobacterium bovis (BCG) infection

neoplasm
• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial chronic myelocytic leukemia-like syndrome DOID:0060761 OMIM:600080
J:97931


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/07/2019
MGI 6.14
The Jackson Laboratory