Phenotypes Associated with This Genotype

Genotype
MGI:3578807

• Allelic Composition: Mef2c^tm1Eno/Mef2c^tm1Eno
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:40724 )

• frequency of homozygous embryos normal up to E9.5

• no viable mutants by E10.5

embryo

abnormal vitelline vasculature morphology ( J:56426 )

• vitelline vein and artery are present but with little or no blood

embryonic growth retardation ( J:40724 )

• growth normal until E9.0

• growth retarded after E9.0

incomplete somite formation ( J:40724 )

• development up to 14 somite stage (E9.0)

• never more than 20 somites formed

cardiovascular system

abnormal cardiovascular system morphology ( J:40724 )

abnormal blood vessel morphology ( J:56426 )

• less branching than normal

• cranial and caudal blood vessels are dilated

• vessels dorsal and rostral to the heart are narrow and sometimes discontinuous

abnormal vitelline vasculature morphology ( J:56426 )

• vitelline vein and artery are present but with little or no blood

abnormal heart development ( J:40724 )

failure of heart looping ( J:40724 )

• heart normal at E8.0-8.25 (linear heart tube)

• looping to the right did not occur

abnormal sinus venosus morphology ( J:40724 )

• sinus venosus frequently not present

ventricular hypoplasia ( J:40724 )

trabecula carnea hypoplasia ( J:40724 )

• lumen of ventricle very narrow

decreased cardiac muscle contractility ( J:40724 )

• contractions initiated but slow and irregular (26 beats/minute as opposed to 58 beats)

• weak atrial chamber beating

decreased ventricle muscle contractility ( J:40724 )

• only vibrates in response to atrium, no independent contractions

hematopoietic system

abnormal definitive hematopoiesis ( J:56426 )

• less blood than normal is present

growth/size/body

embryonic growth retardation ( J:40724 )

• growth normal until E9.0

• growth retarded after E9.0

muscle

trabecula carnea hypoplasia ( J:40724 )

• lumen of ventricle very narrow

decreased cardiac muscle contractility ( J:40724 )

• contractions initiated but slow and irregular (26 beats/minute as opposed to 58 beats)

• weak atrial chamber beating

decreased ventricle muscle contractility ( J:40724 )

• only vibrates in response to atrium, no independent contractions