Phenotypes Associated with This Genotype

Genotype
MGI:3578294

• Allelic Composition: Ajuba^tm1Gdl/Ajuba^tm1Gdl
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell migration ( J:98248 )

• homozygous null MEFs displayed a marked inhibition of migration in a scratch-wound repair assay, covering only 20-30% of the wound area compared to complete wound closure in wildtype, however homozygous null mice were viable and reached adulthood without any obvious phenotypes

• migrating homozygous null MEFs exhibited abnormal lamellipodia production with decreased levels and activation of FAK, p130Cas, and Rac1