About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3578113
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Tg(Alb-cre)21Mgn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 70-90% reduction in plasma phospholipid level
• 2-fold higher catabolism of HDL apoA-I from wildtype mice or human lipid-free ApoA-I than in wildtype, due to a 2-fold increase in the catabolism of apoA-I by the kidney, with no change in liver catabolism
• total plasma cholesterol levels were 80% lower than in wildtype
• 70-90% reduction in plasma free cholesterol and esterified cholesterol
• 80% lower than in wildtype

Mouse Models of Human Disease
OMIM ID Ref(s)
Tangier Disease; TGD 205400 J:98093


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory