Mouse Genome Informatics
cn
    Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0

involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• 70-90% reduction in plasma phospholipid level
• 2-fold higher catabolism of HDL apoA-I from wildtype mice or human lipid-free ApoA-I than in wildtype, due to a 2-fold increase in the catabolism of apoA-I by the kidney, with no change in liver catabolism
• total plasma cholesterol levels were 80% lower than in wildtype
• 70-90% reduction in plasma free cholesterol and esterified cholesterol
• 80% lower than in wildtype

Mouse Models of Human Disease
OMIM IDRef(s)
Tangier Disease; TGD 205400 J:98093