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Phenotypes Associated with This Genotype
Genotype
MGI:3577900
Allelic
Composition
Fktntm1Ttd/Fktntm1Ttd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Ttd mutation (0 available); any Fktn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5 (J:97950)
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5 (J:97950)
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5 (J:97950)
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5 (J:97950)

embryogenesis
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region (J:97950)
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region (J:97950)
• at E6.5 and E7.5, some homozygous null embryos exhibited distorted and folded shapes (J:97950)
• border between epiblast and visceral endoderm is obscure in some E6.5 and E7.5 homozygous null embryos (J:97950)
• at E6.5 and E7.5, some homozygous null embryos exhibited distorted and folded shapes (J:97950)
• border between epiblast and visceral endoderm is obscure in some E6.5 and E7.5 homozygous null embryos (J:97950)
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5 (J:97950)
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5 (J:97950)
• the axis of the egg cylinder is distorted in some E6.5 embryos, so that the ectoplacental cone is attached to the apex (J:97950)
• the axis of the egg cylinder is distorted in some E6.5 embryos, so that the ectoplacental cone is attached to the apex (J:97950)
• Reichert's membrane appeared wavy (J:97950)
• Reichert's membrane appeared wavy (J:97950)
• Reichert's membrane exhibited variable thickness (J:97950)
• Reichert's membrane exhibited variable thickness (J:97950)
• concave face of the folded embryo lacked Reichert's membrane (J:97950)
• concave face of the folded embryo lacked Reichert's membrane (J:97950)
• maternal red blood cells were present in the yolk sac cavity of some E6.5 homozygous null embryos (J:97950)
• maternal red blood cells were present in the yolk sac cavity of some E6.5 homozygous null embryos (J:97950)
• some homozygous null embryos arrest at E7.5 (J:97950)
• some homozygous null embryos arrest at E7.5 (J:97950)

growth/size/body
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5 (J:97950)
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5 (J:97950)

cellular
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region (J:97950)
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region (J:97950)
• basement membrane was thin, partly detached from the plasma membrane, and partly breached (J:97950)
• basement membrane was thin, partly detached from the plasma membrane, and partly breached (J:97950)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory