About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3577900
Allelic
Composition
Fktntm1Ttd/Fktntm1Ttd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Ttd mutation (0 available); any Fktn mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5

embryo
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region
• at E6.5 and E7.5, some homozygous null embryos exhibited distorted and folded shapes
• border between epiblast and visceral endoderm is obscure in some E6.5 and E7.5 homozygous null embryos
• some homozygous null embryos arrest at E7.5
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5
• the axis of the egg cylinder is distorted in some E6.5 embryos, so that the ectoplacental cone is attached to the apex
• Reichert's membrane appeared wavy
• Reichert's membrane exhibited variable thickness
• concave face of the folded embryo lacked Reichert's membrane
• maternal red blood cells were present in the yolk sac cavity of some E6.5 homozygous null embryos

growth/size/body
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5

cellular
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region
• basement membrane was thin, partly detached from the plasma membrane, and partly breached


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory