Mouse Genome Informatics
hm
    Fktntm1Ttd/Fktntm1Ttd
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5
• survival rate decreased gradually during the egg cylinder stage, with no survival beyond E9.5

embryogenesis
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region
• at E6.5 and E7.5, some homozygous null embryos exhibited distorted and folded shapes
• border between epiblast and visceral endoderm is obscure in some E6.5 and E7.5 homozygous null embryos
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5
• the axis of the egg cylinder is distorted in some E6.5 embryos, so that the ectoplacental cone is attached to the apex
• Reichert's membrane appeared wavy
• Reichert's membrane exhibited variable thickness
• concave face of the folded embryo lacked Reichert's membrane
• maternal red blood cells were present in the yolk sac cavity of some E6.5 homozygous null embryos
• some homozygous null embryos arrest at E7.5

growth/size/body
• some embryos were smaller than wildtype at E7.5 and E8.5, with larger extraembryonic portions than embryonic portions at E7.5

cellular
• increased number of apoptotic cells in E6.5 and E7.5 homozygous null embryos, predominantly in the epiblast region
• basement membrane was thin, partly detached from the plasma membrane, and partly breached

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy-Dystroglycanopathy (congenital with Brain and Eye Anomalies), Type A, 4; MDDGA4 253800 J:97950