Phenotypes Associated with This Genotype

Genotype
MGI:3577413

• Allelic Composition: Ppif^tm1Tsu/Ppif^tm1Tsu
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:157346 )

• mouse embryonic fibroblasts exhibit partial resistance to TNF-a, Smac mimetic plus z-VAD induced cell death compared with similarly treated wild-type cells

decreased cellular sensitivity to hydrogen peroxide ( J:97673 )

• increased resistance to hydrogen peroxide induced cell death

abnormal mitochondrial physiology ( J:97673 )

• resistant to swelling and permeability transition induced by treatment with 50 microM calcium ion levels

• greater capacity for calcium uptake

• mitochondrial membrane potential maintained when treated with low concentrations of calcium ion

• resistant to anoxia/reoxygenation injury

cardiovascular system

decreased myocardial infarct size ( J:97673 )

• reducted infarction area when subjected to coronary occlusion followed by reperfusion

homeostasis/metabolism

decreased myocardial infarct size ( J:97673 )

• reducted infarction area when subjected to coronary occlusion followed by reperfusion