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Phenotypes Associated with This Genotype
Genotype
MGI:3576751
Allelic
Composition		 Sh2d1atm1Cpt/Sh2d1a+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation (0 available); any Sh2d1a mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:97756 )
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
abnormal cytokine secretion ( J:97756 )
• IFNG secretion by splenic and hepatic CD8+ T cells is increased after viral infection compared to wild-type mice

hematopoietic system
increased T cell proliferation ( J:97756 )
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice

cellular
increased T cell proliferation ( J:97756 )
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory