Phenotypes for Sh2d1a MGI:3576740 MGI Mouse

immune system

N	• NK T cells are functionally competent in mice on a background with BALB/c unlike in mice on a background with C57BL/6

decreased NK T cell number ( J:189126 )

• reduced in the thymus, spleen and liver

• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6

abnormal germinal center B cell morphology ( J:189126 )

• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice

decreased germinal center B cell number ( J:189126 )

• following immunization with NP-KLH

decreased IgE level ( J:97756 )

• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced

decreased IgG level ( J:189126 )

• NP-specific IgG following immunization with NP-KLH

abnormal cytokine secretion ( J:97756 )

• when activated in vitro by anti-CD3 and anti-CD28 stimulation T cells express very low amounts of IL4, IL10, and IL13; however under polarizing Th2 conditions T cells produce normal amounts of IL4, IL10, and IL13

• after infection with Leishmania major draining lymph node cells produce less IL4, IL10, and IL13

decreased susceptibility to parasitic infection ( J:97756 )

• footpad lesions and parasite burdens are reduced in homozygotes following Leishmania major infection

hematopoietic system