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Phenotypes Associated with This Genotype
Genotype
MGI:3576740
Allelic
Composition
Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation (0 available); any Sh2d1a mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• NK T cells are functionally competent in mice on a background with BALB/c unlike in mice on a background with C57BL/6 (J:189126)
• NK T cells are functionally competent in mice on a background with BALB/c unlike in mice on a background with C57BL/6 (J:189126)
• reduced in the thymus, spleen and liver (J:189126)
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6 (J:189126)
• reduced in the thymus, spleen and liver (J:189126)
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6 (J:189126)
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice (J:189126)
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice (J:189126)
• following immunization with NP-KLH (J:189126)
• following immunization with NP-KLH (J:189126)
• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced (J:97756)
• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced (J:97756)
• NP-specific IgG following immunization with NP-KLH (J:189126)
• NP-specific IgG following immunization with NP-KLH (J:189126)
• when activated in vitro by anti-CD3 and anti-CD28 stimulation T cells express very low amounts of IL4, IL10, and IL13; however under polarizing Th2 conditions T cells produce normal amounts of IL4, IL10, and IL13 (J:97756)
• after infection with Leishmania major draining lymph node cells produce less IL4, IL10, and IL13 (J:97756)
• when activated in vitro by anti-CD3 and anti-CD28 stimulation T cells express very low amounts of IL4, IL10, and IL13; however under polarizing Th2 conditions T cells produce normal amounts of IL4, IL10, and IL13 (J:97756)
• after infection with Leishmania major draining lymph node cells produce less IL4, IL10, and IL13 (J:97756)
• footpad lesions and parasite burdens are reduced in homozygotes following Leishmania major infection (J:97756)
• footpad lesions and parasite burdens are reduced in homozygotes following Leishmania major infection (J:97756)

hematopoietic system
• reduced in the thymus, spleen and liver (J:189126)
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6 (J:189126)
• reduced in the thymus, spleen and liver (J:189126)
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6 (J:189126)
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice (J:189126)
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice (J:189126)
• following immunization with NP-KLH (J:189126)
• following immunization with NP-KLH (J:189126)
• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced (J:97756)
• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced (J:97756)
• NP-specific IgG following immunization with NP-KLH (J:189126)
• NP-specific IgG following immunization with NP-KLH (J:189126)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lymphoproliferative Syndrome, X-Linked, 1; XLP1 308240 J:97756


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory