Mouse Genome Informatics
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    Sh2d1atm1Cpt/Sh2d1atm1Cpt
C.129S4-Sh2d1atm1Cpt
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen

hematopoietic system
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen

Mouse Models of Human Disease
OMIM IDRef(s)
Lymphoproliferative Syndrome, X-Linked, 1; XLP1 308240 J:97388