Mouse Genome Informatics
hm
    Sh2d1atm1Cpt/Sh2d1atm1Cpt
C.129S4-Sh2d1atm1Cpt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses (J:97388)
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)

hematopoietic system
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses (J:97388)
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)

Mouse Models of Human Disease
OMIM IDRef(s)
Lymphoproliferative Syndrome, X-Linked, 1; XLP1 308240 J:97388