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Phenotypes Associated with This Genotype
Genotype
MGI:3576735
Allelic
Composition
Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic
Background
C.129S4-Sh2d1atm1Cpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation (0 available); any Sh2d1a mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles (J:97388)
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses (J:97388)
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses (J:97388)
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)

hematopoietic system
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles (J:97388)
• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses (J:97388)
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses (J:97388)
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lymphoproliferative Syndrome, X-Linked, 1; XLP1 308240 J:97388


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory