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Phenotypes Associated with This Genotype
Genotype
MGI:3576734
Allelic
Composition
Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic
Background
B6.129S4-Sh2d1atm1Cpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation (0 available); any Sh2d1a mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of transitional-2 B lymphocytes in the lymph nodes is decreased (J:97690)
• the number of transitional-2 B lymphocytes in the lymph nodes is decreased (J:97690)
• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased (J:97388)
• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased (J:97388)
• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced (J:97690)
• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced (J:97690)
• CD1d-restricted NKT cells are absent (J:97690)
• CD1d-restricted NKT cells are absent (J:97690)
• IgG viral and T-dependent antigen-specific antibody responses are impaired; however, no defect in T-independent responses is seen (J:97388)
• IgG viral and T-dependent antigen-specific antibody responses are impaired; however, no defect in T-independent responses is seen (J:97388)
• in specific pathogen-free conditions basal serum levels of IgG1 are decreased (J:97388)
• in specific pathogen-free conditions basal serum levels of IgG1 are decreased (J:97388)
• in specific pathogen-free conditions serum IgG2a levels are increased (J:97388)
• in specific pathogen-free conditions serum IgG2a levels are increased (J:97388)
• after viral infection reduced primary antigen-specific IgM responses are seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)
• after viral infection reduced primary antigen-specific IgM responses are seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)

hematopoietic system
• the number of transitional-2 B lymphocytes in the lymph nodes is decreased (J:97690)
• the number of transitional-2 B lymphocytes in the lymph nodes is decreased (J:97690)
• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased (J:97388)
• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased (J:97388)
• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced (J:97690)
• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced (J:97690)
• CD1d-restricted NKT cells are absent (J:97690)
• CD1d-restricted NKT cells are absent (J:97690)
• in specific pathogen-free conditions basal serum levels of IgG1 are decreased (J:97388)
• in specific pathogen-free conditions basal serum levels of IgG1 are decreased (J:97388)
• in specific pathogen-free conditions serum IgG2a levels are increased (J:97388)
• in specific pathogen-free conditions serum IgG2a levels are increased (J:97388)
• after viral infection reduced primary antigen-specific IgM responses are seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)
• after viral infection reduced primary antigen-specific IgM responses are seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lymphoproliferative Syndrome, X-Linked, 1; XLP1 308240 J:97388 , J:97690


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory