Mouse Genome Informatics
hm
    Sh2d1atm1Cpt/Sh2d1atm1Cpt
B6.129S4-Sh2d1atm1Cpt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• the number of transitional-2 B lymphocytes in the lymph nodes is decreased (J:97690)
• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased (J:97388)
• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced (J:97690)
• CD1d-restricted NKT cells are absent (J:97690)
• IgG viral and T-dependent antigen-specific antibody responses are impaired; however, no defect in T-independent responses is seen (J:97388)
• in specific pathogen-free conditions basal serum levels of IgG1 are decreased (J:97388)
• after viral infection reduced primary antigen-specific IgM responses are seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)
• in specific pathogen-free conditions serum IgG2a levels are increased (J:97388)

hematopoietic system
• the number of transitional-2 B lymphocytes in the lymph nodes is decreased (J:97690)
• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased (J:97388)
• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced (J:97690)
• CD1d-restricted NKT cells are absent (J:97690)
• in specific pathogen-free conditions basal serum levels of IgG1 are decreased (J:97388)
• after viral infection reduced primary antigen-specific IgM responses are seen (J:97388)
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen (J:97388)
• in specific pathogen-free conditions serum IgG2a levels are increased (J:97388)

Mouse Models of Human Disease
OMIM IDRef(s)
Lymphoproliferative Syndrome, X-Linked, 1; XLP1 308240 J:97388 , J:97690