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Phenotypes Associated with This Genotype
Genotype
MGI:3576603
Allelic
Composition
Mpztm1Msch/Mpz+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpztm1Msch mutation (0 available); any Mpz mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased infiltration of macrophages into motor nerves
• often found in the endoneurium
• increased numbers of mononuclear cells found in the sciatic nerve
• elevated Th1 autoimmune response to Mpz
• marginally increased production of interferon gamma

behavior/neurological
• waddling gait develops by about 5 months of age
• more prone to experimentally induced paralysis

hematopoietic system
• increased infiltration of macrophages into motor nerves
• often found in the endoneurium
• increased numbers of mononuclear cells found in the sciatic nerve
• elevated Th1 autoimmune response to Mpz

cellular
• increased infiltration of macrophages into motor nerves
• often found in the endoneurium


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory