Mouse Genome Informatics
ht
    Mpztm1Msch/Mpz+
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• increased infiltration of macrophages into motor nerves
• often found in the endoneurium
• increased numbers of mononuclear cells found in the sciatic nerve
• elevated Th1 autoimmune response to Mpz
• marginally increased production of interferon gamma

behavior/neurological
• waddling gait develops by about 5 months of age
• more prone to experimentally induced paralysis

hematopoietic system
• increased infiltration of macrophages into motor nerves
• often found in the endoneurium
• increased numbers of mononuclear cells found in the sciatic nerve
• elevated Th1 autoimmune response to Mpz

cellular
• often found in the endoneurium
• increased infiltration of macrophages into motor nerves

Mouse Models of Human Disease
OMIM IDRef(s)
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, and Hirschsprung Disease; PCWH 609136 J:82432