Mouse Genome Informatics
hm
    Mpztm1Msch/Mpztm1Msch
involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• make fewer turns around axons and otherwise showing varying degrees of abnormal development and degeneration
• schwann cells formed little compacted myelin and that was abnormal
• at 1 year of age, conduction velocities in the sciatic nerve were reduced, temporal dispersion slowed, polyphasia, increased latencies

behavior/neurological
• after 2 weeks of age, body showed weak vibrations when lifted by the tail
• by 4 weeks of age clasping of the hindlimbs when lifted by the tail
• becoming more pronounced with age, sometimes leading to convulsions
• weak forelimbs and hindlimbs in adults
• becoming more pronounced with age
• uncoordinated
• dragging or jerky movements of hindlimbs

Mouse Models of Human Disease
OMIM IDRef(s)
Charcot-Marie-Tooth Disease, Demyelinating, Type 1B; CMT1B 118200 J:42838
Hypertrophic Neuropathy of Dejerine-Sottas 145900 J:42838