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Phenotypes Associated with This Genotype
Genotype
MGI:3576602
Allelic
Composition
Mpztm1Msch/Mpztm1Msch
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpztm1Msch mutation (0 available); any Mpz mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• make fewer turns around axons and otherwise showing varying degrees of abnormal development and degeneration (J:3234)
• make fewer turns around axons and otherwise showing varying degrees of abnormal development and degeneration (J:3234)
• schwann cells formed little compacted myelin and that was abnormal (J:42838)
• schwann cells formed little compacted myelin and that was abnormal (J:42838)
• at 1 year of age, conduction velocities in the sciatic nerve were reduced, temporal dispersion slowed, polyphasia, increased latencies (J:42838)
• at 1 year of age, conduction velocities in the sciatic nerve were reduced, temporal dispersion slowed, polyphasia, increased latencies (J:42838)

behavior/neurological
• after 2 weeks of age, body showed weak vibrations when lifted by the tail (J:3234)
• by 4 weeks of age clasping of the hindlimbs when lifted by the tail (J:3234)
• after 2 weeks of age, body showed weak vibrations when lifted by the tail (J:3234)
• by 4 weeks of age clasping of the hindlimbs when lifted by the tail (J:3234)
• becoming more pronounced with age, sometimes leading to convulsions (J:3234)
• becoming more pronounced with age, sometimes leading to convulsions (J:3234)
• weak forelimbs and hindlimbs in adults (J:3234)
• weak forelimbs and hindlimbs in adults (J:3234)
• becoming more pronounced with age (J:3234)
• becoming more pronounced with age (J:3234)
• uncoordinated (J:3234)
• uncoordinated (J:3234)
• dragging or jerky movements of hindlimbs (J:3234)
• dragging or jerky movements of hindlimbs (J:3234)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory