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Phenotypes Associated with This Genotype
Genotype
MGI:3575737
Allelic
Composition
Sipa1tm1Nm/Sipa1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sipa1tm1Nm mutation (0 available); any Sipa1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• of the 15% (16 out of 102) of heterozygotes with increased WBC counts 4 had chronic myelocytic leukemia in the chronic phase and the other 12 were in blast crisis

hematopoietic system
• 15% of heterozygotes have decreased RBC counts (6.35 +/- 0.6 x 10 6 cells/mm3 compared to 9.32 +/- 0.04 x 106 cells/mm3 in wild-type mice)
• 15% of heterozygotes have increased mean WBC counts (22.3 +/- 5.8 x 10 3 cells/mm3 compared to 8.7 +/- 103 cells/mm3 in wild-type mice)
• this 15% also had splenomegaly

immune system
• 15% of heterozygotes have increased mean WBC counts (22.3 +/- 5.8 x 10 3 cells/mm3 compared to 8.7 +/- 103 cells/mm3 in wild-type mice)
• this 15% also had splenomegaly

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:97239


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory