Phenotypes Associated with This Genotype

Genotype
MGI:3575737

• Allelic Composition: Sipa1^tm1Nm/Sipa1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased chronic myelocytic leukemia incidence ( J:97239 )

• of the 15% (16 out of 102) of heterozygotes with increased WBC counts 4 had chronic myelocytic leukemia in the chronic phase and the other 12 were in blast crisis

hematopoietic system

enlarged spleen ( J:97239 )

• this 15% also had splenomegaly

decreased erythrocyte cell number ( J:97239 )

• 15% of heterozygotes have decreased RBC counts (6.35 +/- 0.6 x 10 ⁶ cells/mm³ compared to 9.32 +/- 0.04 x 10⁶ cells/mm³ in wild-type mice)

increased leukocyte cell number ( J:97239 )

• 15% of heterozygotes have increased mean WBC counts (22.3 +/- 5.8 x 10 ³ cells/mm³ compared to 8.7 +/- 10³ cells/mm³ in wild-type mice)

immune system

enlarged spleen ( J:97239 )

• this 15% also had splenomegaly

increased leukocyte cell number ( J:97239 )

• 15% of heterozygotes have increased mean WBC counts (22.3 +/- 5.8 x 10 ³ cells/mm³ compared to 8.7 +/- 10³ cells/mm³ in wild-type mice)

growth/size/body

enlarged spleen ( J:97239 )

• this 15% also had splenomegaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:97239