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Phenotypes Associated with This Genotype
Genotype
MGI:3575312
Allelic
Composition
Nfe2l1tm1Jefc/Nfe2l1tm1Ywk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l1tm1Jefc mutation (0 available); any Nfe2l1 mutation (10 available)
Nfe2l1tm1Ywk mutation (0 available); any Nfe2l1 mutation (10 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (5 available); any Speer6-ps1 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• note: apoptotic cells and necrosis are seen in 4 weeks old mutant mice liver

neoplasm
• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice
• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice

homeostasis/metabolism

immune system
• infiltration of inflammatory cells are seen in 4 weeks old mutant mice liver

liver/biliary system
• note: apoptotic cells and necrosis are seen in 4 weeks old mutant mice liver
• infiltration of inflammatory cells are seen in 4 weeks old mutant mice liver
• at 4 weeks, fatty vacuolated cells in liver had a 3-fold elevation in triglyceride levels
• lipid accumulation was also seen in cultures of primary hepatocytes derived from mutant mice
• pericentral and pericellular fibrosis was seen in older animals
• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice
• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:97188


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory