Mouse Genome Informatics
hm
    Gnrhrhh/Gnrhrhh
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• the anogenital distance is reduced
• the genital papilla is reduced in size (J:96941)
• overall the adult internal reproductive tract appears prepubescent (J:96941)
• arrest at the early antral stage (J:96941)
• large antral follicles are absent (J:96941)
• the uterus is thread-like and pale (J:96941)
• blocked at the midpachytene stages of meiosis (J:96941)
• the genital papilla is reduced in size (J:96941)
• overall the adult internal reproductive tract appears prepubescent (J:96941)
(J:96941)
(J:96941)
• reduced in size (J:96941)
• ovaries are about 50% the size of normal littermates (J:96941)
• testes weigh 1/10 that of normal littermates (J:96941)
• opening of the vagina is delayed

homeostasis/metabolism
• decreased circulating levels of androstenedione
• the number of FSH positive cells is decreased in the pituitary
• the number of LH positive cells is decreased in the pituitary

renal/urinary system
(J:96941)

endocrine/exocrine glands
• arrest at the early antral stage (J:96941)
• large antral follicles are absent (J:96941)
• ovaries are about 50% the size of normal littermates (J:96941)
• testes weigh 1/10 that of normal littermates (J:96941)
(J:96941)

digestive/alimentary system
• the anogenital distance is reduced

Mouse Models of Human Disease
OMIM IDRef(s)
Hypogonadotropic Hypogonadism 7 with or without Anosmia; HH7 146110 J:96941