Mouse Genome Informatics
hm
    Gnrhrhh/Gnrhrhh
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• the anogenital distance is reduced
• the genital papilla is reduced in size
• overall the adult internal reproductive tract appears prepubescent
• arrest at the early antral stage
• large antral follicles are absent
• the uterus is thread-like and pale
• blocked at the midpachytene stages of meiosis
• the genital papilla is reduced in size
• overall the adult internal reproductive tract appears prepubescent
• reduced in size
• ovaries are about 50% the size of normal littermates
• testes weigh 1/10 that of normal littermates
• opening of the vagina is delayed

homeostasis/metabolism
• decreased circulating levels of androstenedione
• the number of FSH positive cells is decreased in the pituitary
• the number of LH positive cells is decreased in the pituitary

renal/urinary system

endocrine/exocrine glands
• arrest at the early antral stage
• large antral follicles are absent
• ovaries are about 50% the size of normal littermates
• testes weigh 1/10 that of normal littermates

digestive/alimentary system
• the anogenital distance is reduced

Mouse Models of Human Disease
OMIM IDRef(s)
Hypogonadotropic Hypogonadism 7 with or without Anosmia; HH7 146110 J:96941