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Phenotypes Associated with This Genotype
Genotype
MGI:3574973
Allelic
Composition
Gnrhrhh/Gnrhrhh
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrhrhh mutation (0 available); any Gnrhr mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• the anogenital distance is reduced
• the genital papilla is reduced in size
• overall the adult internal reproductive tract appears prepubescent
• arrest at the early antral stage
• large antral follicles are absent
• the uterus is thread-like and pale
• blocked at the midpachytene stages of meiosis
• the genital papilla is reduced in size
• overall the adult internal reproductive tract appears prepubescent
• reduced in size
• ovaries are about 50% the size of normal littermates
• testes weigh 1/10 that of normal littermates
• opening of the vagina is delayed

homeostasis/metabolism
• decreased circulating levels of androstenedione
• the number of FSH positive cells is decreased in the pituitary
• the number of LH positive cells is decreased in the pituitary

renal/urinary system

endocrine/exocrine glands
• arrest at the early antral stage
• large antral follicles are absent
• ovaries are about 50% the size of normal littermates
• testes weigh 1/10 that of normal littermates

digestive/alimentary system
• the anogenital distance is reduced

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypogonadotropic Hypogonadism 7 with or without Anosmia; HH7 146110 J:96941


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory