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Phenotypes Associated with This Genotype
Genotype
MGI:3574885
Allelic
Composition
Mtnr1atm1Rep/Mtnr1atm1Rep
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtnr1atm1Rep mutation (2 available); any Mtnr1a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• although circadian functions were normal, the inhibitory effect of melatonin on suprachiasma neuronal firing was abolished
• phase shifting effect of melatonin on suprachiasma neuronal firing was retained in vitro although the effect was much smaller than controls at highly reduced doses of melatonin


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory