Phenotypes Associated with This Genotype

Genotype
MGI:3574655

• Allelic Composition: Cd36^obl/Cd36^obl
• Genetic Background: C57BL/6-Cd36^obl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:96018 )

• mice die more frequently than wildtype after S. aureus infection

taste/olfaction

abnormal olfaction ( J:236910 )

• mice show decreased investigation time towards a lipid mixture containing saturated and unsaturated long-chain fatty acids indicating altered olfactory behavior upon lipid exposure

• however, mice show normal defensive behaviors upon exposure to predator odors, normal odorant detection in the buried food test, and normal behavior in response to amyl acetate in an odorant preference test

• olfactory epithelium appears normal, the general distribution of supporting cells, ducts, and Bowmans gland and OMP-positive neurons are unaffected, and no gross changes in the olfactory bulb are seen

immune system

abnormal cell-mediated immunity ( J:96018 )

• mice are hyporesponsive to macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae and to a Staphylococcus-derived peptidoglycan

abnormal macrophage physiology ( J:96018 )

• macrophages exhibit a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae

endophthalmitis ( J:96018 )

• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball

increased susceptibility to bacterial infection ( J:96018 )

• during a 7-dap period, homozygous mutant mice were permissive for the growth of intradermally inoculated S. aureus, whereas the bacteria were cleared from wildtype

vision/eye

endophthalmitis ( J:96018 )

• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball

ocular pterygium ( J:96018 )

• homozygotes all develop an ocular pterygium by 6-12 months of age, apparently as the result of spontaneous colonization with Corynebacterium and Staphylococcus lenus

hematopoietic system

abnormal macrophage physiology ( J:96018 )

• macrophages exhibit a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae