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Phenotypes Associated with This Genotype
Genotype
MGI:3574655
Allelic
Composition
Cd36obl/Cd36obl
Genetic
Background
C57BL/6-Cd36obl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd36obl mutation (1 available); any Cd36 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die more frequently than wildtype after S. aureus infection

taste/olfaction
• mice show decreased investigation time towards a lipid mixture containing saturated and unsaturated long-chain fatty acids indicating altered olfactory behavior upon lipid exposure
• however, mice show normal defensive behaviors upon exposure to predator odors, normal odorant detection in the buried food test, and normal behavior in response to amyl acetate in an odorant preference test
• olfactory epithelium appears normal, the general distribution of supporting cells, ducts, and Bowmans gland and OMP-positive neurons are unaffected, and no gross changes in the olfactory bulb are seen

immune system
• mice are hyporesponsive to macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae and to a Staphylococcus-derived peptidoglycan
• macrophages exhibit a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae
• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball
• during a 7-dap period, homozygous mutant mice were permissive for the growth of intradermally inoculated S. aureus, whereas the bacteria were cleared from wildtype

vision/eye
• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball
• homozygotes all develop an ocular pterygium by 6-12 months of age, apparently as the result of spontaneous colonization with Corynebacterium and Staphylococcus lenus

hematopoietic system
• macrophages exhibit a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae

Mouse Models of Human Disease
OMIM ID Ref(s)
Pterygium of Conjunctiva and Cornea 178000 J:96018


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory