Mouse Genome Informatics
hm
    Cd36obl/Cd36obl
C57BL/6-Cd36obl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• died more frequently than wildtype after S. aureus infection

immune system
• homozygous mutants were hyporesponsive to macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae and to a Staphylococcus-derived peptidoglycan
• macrophages exhibited a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae
• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball
• during a 7-dap period, homozygous mutant mice were permissive for the growth of intradermally inoculated S. aureus, whereas the bacteria were cleared from wildtype

vision/eye
• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball
• homozygotes all develop an ocular pterygium by 6-12 months of age, apparently as the result of spontaneous colonization with Corynebacterium and Staphylococcus lenus

hematopoietic system
• macrophages exhibited a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae

Mouse Models of Human Disease
OMIM IDRef(s)
Pterygium of Conjunctiva and Cornea 178000 J:96018