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Phenotypes Associated with This Genotype
Genotype
MGI:3574655
Allelic
Composition
Cd36obl/Cd36obl
Genetic
Background
C57BL/6-Cd36obl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd36obl mutation (1 available); any Cd36 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died more frequently than wildtype after S. aureus infection

immune system
• homozygous mutants were hyporesponsive to macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae and to a Staphylococcus-derived peptidoglycan
• macrophages exhibited a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae
• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball
• during a 7-dap period, homozygous mutant mice were permissive for the growth of intradermally inoculated S. aureus, whereas the bacteria were cleared from wildtype

vision/eye
• on occasion spontaneous colonization with Corynebacterium and Staphylococcus lenus progresses to spontaneous endophthalmitis, an inflammation of the internal structures of the tissues in the eyeball
• homozygotes all develop an ocular pterygium by 6-12 months of age, apparently as the result of spontaneous colonization with Corynebacterium and Staphylococcus lenus

hematopoietic system
• macrophages exhibited a reduction in TNF production in response to Staphylococcus-derived peptidoglcan and synthetic macrophage-activating lipopeptide 2 (MALP-2) from Mycoplasma pneumoniae

Mouse Models of Human Disease
OMIM ID Ref(s)
Pterygium of Conjunctiva and Cornea 178000 J:96018


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory