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Phenotypes Associated with This Genotype
Genotype
MGI:3574545
Allelic
Composition
Dok1tm1Ppp/Dok1+
Tg(BCR/ABL1)5Hhi/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (7 available)
Tg(BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• loss of Dok1 shortened lifespan to about 307 days from about 325 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok1

neoplasm
• inactivation of Dok1 accelerated the onset of the chronic phase and the fatal blastic phase
• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:95334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory