Phenotypes Associated with This Genotype

Genotype
MGI:3574543

• Allelic Composition: Dok1^tm1Ppp/Dok1^tm1Ppp; Dok2^tm1Ppp/Dok2^tm1Ppp
• Genetic Background: 129S1/Sv-Dok1^tm1Ppp Dok2^tm1Ppp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:95334 )

• double homozygotes develop chronic myeloid leukemia-like myeloproliferative disease at 10-12 months of age

• this myeloproliferative disease is fully transplantable

increased lung adenocarcinoma incidence ( J:158011 )

• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

hematopoietic system

enlarged spleen ( J:95334 )

increased bone marrow cell number ( J:95334 )

• bone marrow hypercellularity and infiltration by myeloid cells that retain the ability to terminally differentiate are seen

increased leukocyte cell number ( J:95334 )

• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age

• infiltration by myeloid cells that retain the ability to terminally differentiate is seen

increased neutrophil cell number ( J:95334 )

increased monocyte cell number ( J:95334 )

abnormal leukocyte physiology ( J:95334 )

• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

immune system

enlarged spleen ( J:95334 )

increased leukocyte cell number ( J:95334 )

• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age

• infiltration by myeloid cells that retain the ability to terminally differentiate is seen

increased neutrophil cell number ( J:95334 )

increased monocyte cell number ( J:95334 )

abnormal leukocyte physiology ( J:95334 )

• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

respiratory system

increased lung adenocarcinoma incidence ( J:158011 )

• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

growth/size/body

enlarged spleen ( J:95334 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95334