About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3574543
Allelic
Composition
Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Genetic
Background
129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (7 available)
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

neoplasm
• double homozygotes develop chronic myeloid leukemia-like myeloproliferative disease at 10-12 months of age
• this myeloproliferative disease is fully transplantable
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

hematopoietic system
• bone marrow hypercellularity and infiltration by myeloid cells that retain the ability to terminally differentiate are seen
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

immune system
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:95334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory