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Phenotypes Associated with This Genotype
Genotype
MGI:3574543
Allelic
Composition
Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Genetic
Background
129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (4 available)
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

neoplasm
• double homozygotes develop chronic myeloid leukemia-like myeloproliferative disease at 10-12 months of age
• this myeloproliferative disease is fully transplantable
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

hematopoietic system
• bone marrow hypercellularity and infiltration by myeloid cells that retain the ability to terminally differentiate are seen
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

immune system
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory