Mouse Genome Informatics
cx
    Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp

129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• double homozygotes develop chronic myeloid leukemia-like myeloproliferative disease at 10-12 months of age
• this myeloproliferative disease is fully transplantable
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

hematopoietic system
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• bone marrow hypercellularity and infiltration by myeloid cells that retain the ability to terminally differentiate are seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

immune system
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

Mouse Models of Human Disease
OMIM IDRef(s)
Leukemia, Chronic Myeloid; CML 608232 J:95334
Myeloproliferative Disorder, Chronic, with Eosinophilia 131440 J:95334