Phenotypes Associated with This Genotype

Genotype
MGI:3574540

• Allelic Composition: Dok1^tm1Ppp/Dok1^tm1Ppp
• Genetic Background: 129S1/Sv-Dok1^tm1Ppp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell proliferation ( J:95640 )

• thymocytes display increased proliferation in response to ConA stimulation

neoplasm

increased lung adenocarcinoma incidence ( J:158011 )

• at 11-25 months, 38% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

cellular

abnormal T cell proliferation ( J:95640 )

• thymocytes display increased proliferation in response to ConA stimulation

increased fibroblast proliferation ( J:95640 )

• primary embryonic fibroblasts display increased proliferation in response to PDGF stimulation

hematopoietic system

abnormal T cell proliferation ( J:95640 )

• thymocytes display increased proliferation in response to ConA stimulation

abnormal bone marrow cell morphology/development ( J:95640 )

• bone marrow derived mast cells display increased proliferation in response to low concentrations of cytokines; however, when deprived of cytokines mutant cells underwent apoptosis similar to wild-type cells

respiratory system

increased lung adenocarcinoma incidence ( J:158011 )

• at 11-25 months, 38% of mice develop lung adenocarcinoma compared with 7% of wild-type mice