Phenotypes Associated with This Genotype

Genotype
MGI:3574185

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:76336 )

• when fed high-cholesterol, high-fat diet containing cholate for 4 weeks, 40% decrease in atherosclerosis lesion size when compared to homozygous single Ldlr^tm1Her mutant mice

homeostasis/metabolism

increased circulating cholesterol level ( J:76336 )

• 40% increase in total plasma cholesterol (non-HDL) when fed cholesterol-fat enriched Western diet for 10 weeks; slight increase in total plasma cholesterol level when fed high-cholesterol, high-fat diet containing cholate for 4 weeks

increased circulating triglyceride level ( J:76336 )

• 40% increase in total plasma triglyceride level when fed cholesterol-fat enriched Western diet for 10 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial hypercholesterolemia		DOID:13810	OMIM:143890	J:76336