Phenotypes Associated with This Genotype

Genotype
MGI:3574083

• Allelic Composition: Olig3^tm1Tre/Olig3^tm1Tre
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:96749 )

• the number of neurons generated in the dorsal alar plate was reduced at E11.5

abnormal neuronal migration ( J:96749 )

• differences in the migration of class A neurons were apparent at E11 and more pronounced by E12.5, as observed by ectopically located neurons in the lateral positions of the dorsal spinal cord and at sites typically occupied by class B neurons

abnormal neuron specification ( J:96749 )

• a reduction of the numbers of dI1 neurons in the dorsal spinal cord, the alar plate, and no generation of dI2 and dI3 neurons, instead ectopic neurons of the class B (dI4) appear in the dorsal alar plate indicating that class A (dI2 and dI3) neurons were not correctly specified and assume the fate of class B neuronal subtype

cellular

abnormal neuron differentiation ( J:96749 )

• the number of neurons generated in the dorsal alar plate was reduced at E11.5

abnormal neuronal migration ( J:96749 )

• differences in the migration of class A neurons were apparent at E11 and more pronounced by E12.5, as observed by ectopically located neurons in the lateral positions of the dorsal spinal cord and at sites typically occupied by class B neurons