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Phenotypes Associated with This Genotype
Genotype
MGI:3573927
Allelic
Composition
Htttm1Detl/Htttm1Detl
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm1Detl mutation (0 available); any Htt mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• during tail suspension, a similar % (<20%) of wild-type and homozygous mutant mice tend to clasp
• at >40 weeks of age, homozygotes show an increase in the average distance between front and hind paws ('overlap' distance) relative to wild-type mice
• 1 out of 10 homozygotes (100 trials; 25-60 weeks of age) exhibit a convulsive spell consistent with a tonic-clonic seizure

growth/size/body
• at 34 weeks of age, some homozygotes exhibit an extreme size reduction relative to wild-type mice

homeostasis/metabolism
N
• homozygotes display normal blood glucose levels relative to wild-type mice

nervous system
N
• homozygotes display no extreme reductions in major brain regions or significant reactive gliosis relative to wild-type mice
• 1 out of 10 homozygotes (100 trials; 25-60 weeks of age) exhibit a convulsive spell consistent with a tonic-clonic seizure
• neuronal intranuclear inclusions (NIIs) are rarely observed in homozygotes up to 90 weeks of age; no NIIs are noted in wild-type brains

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:67074


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory