Mouse Genome Informatics
hm
    Htttm1Detl/Htttm1Detl
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• during tail suspension, a similar % (<20%) of wild-type and homozygous mutant mice tend to clasp (J:67074)
• at >40 weeks of age, homozygotes show an increase in the average distance between front and hind paws ('overlap' distance) relative to wild-type mice
• 1 out of 10 homozygotes (100 trials; 25-60 weeks of age) exhibit a convulsive spell consistent with a tonic-clonic seizure

growth/size
• at 34 weeks of age, some homozygotes exhibit an extreme size reduction relative to wild-type mice

homeostasis/metabolism
N
• homozygotes display normal blood glucose levels relative to wild-type mice (J:67074)

nervous system
N
• homozygotes display no extreme reductions in major brain regions or significant reactive gliosis relative to wild-type mice (J:67074)
• 1 out of 10 homozygotes (100 trials; 25-60 weeks of age) exhibit a convulsive spell consistent with a tonic-clonic seizure
• neuronal intranuclear inclusions (NIIs) are rarely observed in homozygotes up to 90 weeks of age; no NIIs are noted in wild-type brains

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:67074