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Phenotypes Associated with This Genotype
Genotype
MGI:3531409
Allelic
Composition
Phox2a/Inppl1tm1Ssch/Phox2a+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2a/Inppl1tm1Ssch mutation (0 available); any Phox2a mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• injection of insulin caused more profound hypoglycemia in heterozygotes than in wild-type mice

homeostasis/metabolism
• injection of D-glucose resulted in a more rapid glucose clearance in heterozygous compared to wild-type
• in response to insulin stimulation GLUT4 glucose transporter and glycogen synthesis are increased more profoundly in skeletal muscle of heterozygotes compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:96443


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory