Mouse Genome Informatics
cn
    Ppp3r1tm1Stl/Ppp3r1tm1Stl
Tg(Camk2a-cre)CW2Stl/0

C57BL/6-Ppp3r1tm1Stl Tg(Camk2a-cre)CW2Stl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• appear normal and healthy, but prone to sudden death, with ~50% dead by 6 months of age

behavior/neurological
• decreased working/episodic-like memory in delayed matching-to-place test, however memory extinction are normal
• impaired latent inhibition in cued testing; however motor coordination, pain sensitivity, and cued fear conditioning are normal
• reduced spatial working memory in radial maze test, however in a morris water maze test spatial reference memory appeared normal
• nests poorly formed

nervous system
• significantly lower prepulse inhibition
• seen in Schaffer collateral-CA1 synapse in hippocampal slices and at frequencies where LTD and LTP compete LTP is favored

growth/size/body
• 12% smaller than wild-type littermates

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:73203 , J:84640