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Phenotypes Associated with This Genotype
Genotype
MGI:3530740
Allelic
Composition
Ppp3r1tm1Stl/Ppp3r1tm1Stl
Tg(Camk2a-cre)CW2Stl/0
Genetic
Background
C57BL/6-Ppp3r1tm1Stl Tg(Camk2a-cre)CW2Stl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3r1tm1Stl mutation (1 available); any Ppp3r1 mutation (24 available)
Tg(Camk2a-cre)CW2Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• appear normal and healthy, but prone to sudden death, with ~50% dead by 6 months of age

behavior/neurological
• decreased working/episodic-like memory in delayed matching-to-place test, however memory extinction are normal
• impaired latent inhibition in cued testing; however motor coordination, pain sensitivity, and cued fear conditioning are normal
• reduced spatial working memory in radial maze test, however in a morris water maze test spatial reference memory appeared normal
• nests poorly formed

nervous system
• significantly lower prepulse inhibition
• seen in Schaffer collateral-CA1 synapse in hippocampal slices and at frequencies where LTD and LTP compete LTP is favored

growth/size/body
• 12% smaller than wild-type littermates

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:73203 , J:84640


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory